Academica Weekly: The Primary Record for the Week Ending 4 October 2026
Trial registrations, clearances, recalls, guidance, safety reports, device listings, and insider filings — assembled from the primary sources with no editor in the loop.
The week of 28 September 2026 to 4 October 2026: 41 Phase 3 trial registrations; 91 Phase 2 trial registrations; 7 recall events; 157 510(k) clearances; 216 new Health Canada device licences; 4,237 ARTG device entries; 493 open-market insider purchases.
41 Phase 3 trial registrations
91 Phase 2 trial registrations
7 recall events
157 510(k) clearances
71Phase 1 registrations91Phase 2 registrations41Phase 3 registrations45Phase 4 registrations157510(k) clearances269PMA decisions7recall events352,949adverse event reports439,212device event reports25,552device listings4,237ARTG device entries216new device licences7label effective dates65,735new provider enumerations15,384,974industry payments95medtech patent grants123,818literature records493open-market insider purchases
Source Ledger
The latest event date each source holds, measured against its expected publication cadence. A stale source keeps its ledger line and loses its section.
| Source | Latest event | State |
|---|---|---|
| ClinicalTrials.govPhase 1 · Phase 2 · Phase 3 · Phase 4 | 2 October 2026 | Current |
| FDA 510(k) | 19 September 2026 | 15 days behind |
| FDA PMA | 18 September 2026 | Current |
| FDA recalls | 29 September 2026 | Current |
| FDA guidance | 25 September 2026 | Current |
| FAERS | 30 June 2026 | Current |
| MAUDE | 31 August 2026 | Current |
| GUDID | 26 July 2026 | 70 days behind |
| TGA ARTG | 2 October 2026 | Current |
| Health Canada | 2 October 2026 | Current |
| FDA drug labels | 1 October 2026 | 3 days behind |
| NPPES | 12 September 2026 | Current |
| Open Payments | 31 December 2024 | 642 days behind |
| USPTO | 10 February 2026 | 236 days behind |
| PubMed | 3 October 2026 | Current |
| SEC Form 4 | 2 October 2026 | Current |
Phase 1 Trials
71 Phase 1 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| CD19 CAR-T Therapy for Refractory Childhood-Onset Systemic Lupus Erythematosus | Seoul National University Hospital | 8 | ||
| A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS) | Biogen | 69 | ||
| A Research Study Investigating How Adults With Overweight or Obesity, With or Without Type 2 Diabetes, Tolerate Switching to a New Treatment (Zenagamtide) From Their Current Semagl | Novo Nordisk A/S | 60 | ||
| A Clinical Trial of V175 and V175A in Healthy Adults | Merck Sharp & Dohme LLC | 564 | ||
| First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE-4D Imaging in Healthy Volunteers | National Institute of Mental Health (NIMH) | 40 | ||
| A Study to Explore the Tissue Level Effects of Remibrutinib in Adults With Moderate to Severe HS | Novartis Pharmaceuticals | 30 | ||
| A Study to Evaluate the Pharmacokinetics and Safety of INCB161734 in Participants With Impaired Renal Function and Participants on Hemodialysis | Incyte Corporation | 24 | ||
| A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Tacabrutideg (BGB-16673) in Participants With Moderate and Severe Hepatic Impairment | BeOne Medicines | 24 | ||
| Safety and Preliminary Efficacy of Adipose-Derived Stem Cell Secretome in Frailty (VinVital) | Vinmec Research Institute of Stem Cell and Gene Technology | 20 | ||
| Safety and Immunogenicity of a Combined Diphtheria, Tetanus, Whole Cell Pertussis, Hepatitis B, Recombinant Poliomyelitis and Haemophilus Influenzae Type b (Hib) Vaccine (SIIPL DTw | Serum Institute of India Pvt. Ltd. | 186 |
Phase 2 Trials
91 Phase 2 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| The Clinical Trial of Tamibarotene for Patients With HFpEF (RELIEF Trial) | Nagoya University | 90 | ||
| A Phase II Study of Ivonescimab in Combination With GEMOX as Neoadjuvant and Conversion Therapy for Biliary Tract Cancer | Haitao Zhao, MD | 87 | ||
| Arsenic Trioxide Combined With Chemotherapy for Relapsed SHH-Activated and/or TP53-Mutant Medulloblastoma | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 78 | ||
| A Clinical Study to Assess Safety, Efficacy and Pharmacodynamic Profile of GNT0004 in Duchenne Muscular Dystrophy | Genethon | 77 | ||
| A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS) | Biogen | 69 | ||
| Topical Dexamethasone/Diclofenac Hydrogel for Postoperative Pain and Swelling in Facial Soft Tissue Injuries | Thamar University | 52 | ||
| Multicenter, Single-Arm, Prospective Phase II Study of Neoadjuvant Cryo-Thermal Ablation Combined With Toripalimab and Chemotherapy for Resectable Stage IB-IIIB Non-Small Cell Lung | West China Hospital | 40 | ||
| Fecal Microbiota Transplantation Combined With NALIRIFOX Plus Serplulimab as First-line Treatment for Advanced or Metastatic Pancreatic Ductal Adenocarcinoma. | Tianjin Medical University Cancer Institute and Hospital | 40 | ||
| SHR-A1811 Versus Trastuzumab Plus Pertuzumab in ctDNA-Positive HER2-Positive Early Breast Cancer After Pathologic Complete Response | Fudan University | 358 | ||
| A Prospective Clinical Study of Zeprumetosta in Patients With Relapsed or Refractory Cutaneous T-Cell Lymphoma | Peking University First Hospital | 33 |
Phase 3 Trials
41 Phase 3 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| A Clinical Study to Assess Safety, Efficacy and Pharmacodynamic Profile of GNT0004 in Duchenne Muscular Dystrophy | Genethon | 77 | ||
| A Study of JNJ-99245354 (ITI-1284) as an Adjunctive Treatment in Participants With Generalized Anxiety Disorder (GAD) Who Have an Inadequate Response to GAD Treatment | Intra-Cellular Therapies, Inc. | 705 | ||
| A Study to Evaluate the Efficacy and Safety of Proximod in Patients With Rheumatoid Arthritis | Jiankuan (Suzhou) Biotechnology Company Limited | 590 | ||
| Topical Dexamethasone/Diclofenac Hydrogel for Postoperative Pain and Swelling in Facial Soft Tissue Injuries | Thamar University | 52 | ||
| SYNCHRONIZE®-START- A Study to Test Whether Survodutide Helps People Living With Overweight or Obesity Who do Not Have Diabetes to Lose Weight | Boehringer Ingelheim | 350 | ||
| Study Interchangeability Hep-B Vaccine Administered at Birth Dose | PT Bio Farma | 270 | ||
| Use of Preoperative Gas in Eyes With Macula-off Rhegmatogenous Retinal Detachment (RRD) | Wills Eye | 190 | ||
| Trial to Evaluate ALN-CIDEB in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) | Regeneron Pharmaceuticals | 1,500 | ||
| Torvutatug Samrotecan Plus Bevacizumab as First-line Maintenance in Homologous Recombination Deficiency (HRD) Negative Advanced Epithelial Ovarian Cancer | AstraZeneca | 950 | ||
| Prophylactic Antibiotic Duration in Head and Neck Cancer Surgery: A Pragmatic, Open-Label, Randomized Superiority Trial (PROTECT-HN Trial) | AC Camargo Cancer Center | 80 |
Phase 4 Trials
45 Phase 4 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| Effect of Preoperative Intranasal Dexmedetomidine on Incidence of Intraoperative Shivering in Patients Undergoing Cesarean Section Under Spinal Anesthesia | Assiut University | 99 | ||
| Nortriptyline Compared With Amitriptyline for Migraine Prevention at SQUH | Sultan Qaboos University | 90 | ||
| Intravenous Paracetamol Versus Magnesium Sulfate for Control of Shivering Following Spinal Anesthesia in Cesarean Section | Assiut University | 90 | ||
| A Study of QL1706 Combined With OH2 Injection in Perioperative Treatment of Stage III Resectable Acral Melanoma | Peking University Cancer Hospital & Institute | 76 | ||
| Reconsidering Long-Term Apirin in the Elderly in Secondary Prevention of Coronary Artery Disease Norway | Vestre Viken Hospital Trust | 7,000 | ||
| Intraosseous Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty | The Second Affiliated Hospital of Kunming Medical University | 70 | ||
| Clinical Lid Eradication of Antifungal-Responsive FUNGUS Study | Brent Kramer | 60 | ||
| Low-Volume PENG Block With Dexamethasone vs Standard-Volume PENG Block After Total Hip Arthroplasty | Ain Shams University | 60 | ||
| Tobramycin Nebulization to Prevent Multidrug-Resistant Ventilator-Associated Pneumonia | Second Affiliated Hospital, Zhejiang University, School of Medicine | 574 | ||
| Suzetrigine Following Urogynecologic Surgery: Investigation of Postoperative Pain Management | Aditi Talkad | 48 |
510(k) Clearances
157 510(k) clearances this week; the 10 below lead the list.
| K number | Device | Applicant | Class | Decision |
|---|---|---|---|---|
| Dynamis Pro Family | Fotona D.O.O. | 2 | ||
| SmartIPL_NI System | Lumenis Be, Ltd. | 2 | ||
| Electric Scooter (FDB08, FDB08A, FDB12) | Anhui JBH Medical Apparatus Co., Ltd. | 2 | ||
| NORMOFLO Irrigation Fluid Warming Sets and Accessories (IR-601, IR-501, IR-61, PL-61) | ICU Medical | 2 | ||
| VacHeal Negative Pressure Wound Therapy System | VacHeal, LLC | 2 | ||
| Mesh Nebulizer (UN204); Mesh Nebulizer (UN205); Mesh Nebulizer (UN209); Mesh Nebulizer (UN210) | Shenzhen Mericonn Technology Co., Ltd. | 2 | ||
| Drainage Catheter | Canyon Medical, Inc. | 2 | ||
| MINT MONO Sutures | Hans Biomed Corporation | 2 | ||
| Deterioration Index Version 2 | Epic Systems Corporation | 2 | ||
| Dental Diode Laser Device (Laser-Pen) | Guilin Kevin Peter Technology Co., Ltd. | 2 |
PMA Approvals
269 PMA decisions this week; the 10 below lead the list.
| PMA | Device | Applicant | Decision |
|---|---|---|---|
| SURGIFOAM® Absorbable Gelatin Sponge | Ferrosan Meidcal Devices A/S | ||
| SELUTION SLR 014 PTCA Drug-Eluting Balloon | MedAlliance, LLC | ||
| Novocure GmbHs Optune Gio | Novocure, GmbH | ||
| Restylane® Contour | Q-Med AB | ||
| Quattrode®; Octrode; Penta; Lamitrode; Tripole; TriCentrus Lead Extensions | Abbott Medical | ||
| Epic Plus, Epic Plus Supra, Epic Max, Epic Elite, Epic Supra G3 Tissue Heart Valves | Abbott Medical | ||
| FoundationOne Liquid CDx (F1LCDx) | Foundation Medicine, Inc. | ||
| Collastat Absorbable Collagen Hemostatic Sponge and Collastat Absorbable Collagen Hemostatic Agent - Microfibrillar Fo | Integra LifeSciences Corporation | ||
| Guardant360 CDx | Guardant Health, Inc. | ||
| INTEGRA ® Dermal Regeneration Template, Integra® Meshed Dermal Regeneration Template, and Integra® Omnigraft Dermal Rege | Integra Lifesciences Corp. |
Recalls
7 recall events this week.
| Firm | Product | Reason | Catalog rows | Posted |
|---|---|---|---|---|
| Tandem Diabetes Care, Inc. | Brand Name: Tandem t:slim mobile application Product Name: t:slim Mobile Application, iOS Model/Catalog Number: iOS software version 2.13 Software Version: iOS software version 2.13 UDI-DI: 0038915247 | A beta (early-release) version of the iOS application, version 2.13 (TestFlight) had a software issue preventing successful pairing of the t:slim application with Abbott FreeStyle Libre 3 Plus (FSL3P) continuous glucose monitoring (CGM) sen | 1 | |
| Philips North America Llc | Philips Medical Systems Technologies Ltd. Spectral CT 7500, Software V5.2.x, Product Code 728333 | The Bolus tracking scan application may crash with a system error message. Bolus Tracker shots may continue to occur even if the contrast threshold is reached. This may result in the patient receiving additional radiation. | 1 | |
| Penumbra Inc. | Brand Name: Penumbra System (RED 62 Reperfusion Catheter) Product Name: Penumbra System (RED 62 Reperfusion Catheter) Model/Catalog Number: THNDRRED62SKIT Software Version: N/A Product Description | Due to manufacturing issues reperfusion catheters may fracture. | 1 | |
| Olympus Corporation of the Americas | Olympus Tripp-Lite P580-025 25ft DisplayPort Cable, Model Number P580-025, an accessory used in conjunction wtih OLYSENSE Hub System | While in the high-power operating mode, a video dropout/blackout may occur when using a particular accessory cable. | 1 | |
| Spectrum Medical SRL | Brand Name: Quantum PureFlow Product Name: Quantum PureFlow Standard Heat Exchanger High Flow 3/8 W Model/Catalog Number: HX55V-S0W Software Version: N/A Product Description: The Quantum PureFlow | Due to blood-to-glycol leak in the heat exchanger. | 2 | |
| Percussionaire Corporation | Intrapulmonary Percussive Ventilation, IPV-2C, Product Number: S00002-C; Phasitron 5, Product Number: P5 used with Instruction Manual | Labeling updated warning not to use Intrapulmonary percussive ventilation (IPV) in conjunction with volatile anesthetic delivery systems because IPV may alter controlled delivery of volatile anesthetic agents, resulting in deeper/lighter an | 7 | |
| Micro Therapeutics, Inc. | Pipeline Flex Embolization Device with Shield Technology REF PED2-300-12 UDI-DI code: 00763000448806 he Pipeline Flex Embolization Device with Shield Technology consists of a permanent implant com | Due to incorrect label/product dimensions. Product is supposed to be 3.00 mm in diameter, but unit is packaging was a 2.50 mm in diameter. | 1 |
Drug Safety Reports (FAERS)
352,949 adverse event reports this week; the 10 below lead the list.
| Reaction | Reports |
|---|---|
| Off label use | 19,437 |
| Drug ineffective | 17,826 |
| Nausea | 13,583 |
| Product dose omission issue | 12,230 |
| Diarrhoea | 12,101 |
| Death | 11,969 |
| Fatigue | 11,899 |
| Pruritus | 10,348 |
| Headache | 9,032 |
| Meningioma | 8,392 |
Device Safety Reports (MAUDE)
439,212 device event reports this week; the 10 below lead the list.
| Brand | Manufacturer | Events |
|---|---|---|
| FreeStyle Libre 2 | 47,720 | |
| FreeStyle Libre 3 | 26,371 | |
| FreeStyle Libre 3 Plus | 22,199 | |
| Dexcom G7 Continuous Glucose Monitoring System | 21,690 | |
| FreeStyle Libre 2 Plus | 18,829 | |
| Medline | 16,603 | |
| Inset Guard | 16,392 | |
| FreeStyle Libre 14 Day | 9,474 | |
| t:slim X2 Insulin Pump with Control-IQ Technology | 9,380 | |
| t:slim X2 Insulin Pump with Control-IQ+ Technology | 7,573 |
Device Listings (GUDID)
25,552 device listings this week; the 10 below lead the list.
| Brand | Company | GMDN | Published |
|---|---|---|---|
| Aligned Medical Solutions | Aligned Medical Solutions | General surgical procedure kit, non-medicated, single-use | |
| Aligned Medical Solutions | Aligned Medical Solutions | General surgical procedure kit, non-medicated, single-use | |
| MyCareLink™ | Medtronic, Inc. | Cardiac pulse generator reader, home-use | |
| Millennium | Avalign Technologies, Inc. | Tendon stripper | |
| Millennium | Avalign Technologies, Inc. | Orthopaedic joint/limb rongeur | |
| Aligned Medical Solutions | Aligned Medical Solutions | Orthopaedic surgical procedure kit, non-medicated, single-use | |
| Aligned Medical Solutions | Aligned Medical Solutions | Ophthalmic surgical procedure kit, non-medicated, single-use | |
| Medtronic Reusable Instruments | Medtronic Sofamor Danek, Inc. | Surgical screwdriver, reusable | |
| Orient Gene | Zhejiang Orient Gene Biotech Co.,Ltd. | Total human chorionic gonadotropin IVD, kit, rapid ICT, self-testing | |
| Aligned Medical Solutions | Aligned Medical Solutions | General surgical procedure kit, non-medicated, single-use |
Australia (TGA ARTG)
4,237 ARTG device entries this week; the 10 below lead the list.
| Brand | Manufacturer | Sponsor | Class | Effective |
|---|---|---|---|---|
| Gia | Covidien llc | Medtronic Australasia Pty Ltd | Class III | |
| Nylus | TI Medical Private Limited | Device Technologies Australia Pty Ltd | Class IIb | |
| Dental Cone-beam Computed Tomography | Hefei Meyer Optoelectronic Technology Inc | MDSS AU Pty Ltd | Class IIb | |
| Nylus | TI Medical Private Limited | Device Technologies Australia Pty Ltd | Class IIb | |
| Nylus | TI Medical Private Limited | Device Technologies Australia Pty Ltd | Class IIb | |
| Nylus | TI Medical Private Limited | Device Technologies Australia Pty Ltd | Class IIb | |
| Nylus | TI Medical Private Limited | Device Technologies Australia Pty Ltd | Class IIb | |
| Dental Cone-beam Computed Tomography | Hefei Meyer Optoelectronic Technology Inc | MDSS AU Pty Ltd | Class IIb | |
| Nylus | TI Medical Private Limited | Device Technologies Australia Pty Ltd | Class IIb | |
| Solus 910 | TI Medical Private Limited | Device Technologies Australia Pty Ltd | Class III |
Canada (Health Canada MDALL)
216 new device licences this week; the 10 below lead the list.
| Device | Company | Class | Licensed |
|---|---|---|---|
| Enteral Funnel Enfit Transition Connector with Cap | Cedic SRL | 2 | |
| Instrument R1D | W&H Dentalwerk Burmoos GmbH | 2 | |
| Instrument Set Special | W&H Dentalwerk Burmoos GmbH | 2 | |
| Instrument Set Endo | W&H Dentalwerk Burmoos GmbH | 2 | |
| Instrument Set Paro | W&H Dentalwerk Burmoos GmbH | 2 | |
| Instrument Set Ex | W&H Dentalwerk Burmoos GmbH | 2 | |
| Instrument Set Implant/Crestal A | W&H Dentalwerk Burmoos GmbH | 2 | |
| Instrument Set Implant/Crestal P | W&H Dentalwerk Burmoos GmbH | 2 | |
| Instrument B1 | W&H Dentalwerk Burmoos GmbH | 2 | |
| Instrument B2L | W&H Dentalwerk Burmoos GmbH | 2 |
Drug Labels
7 label effective dates this week; the 4 below lead the list.
| Brand | Generic | Manufacturer | Effective |
|---|---|---|---|
| Ultra Violette Sheen Screen Broad Spectrum Hydrating Lip Balm Dusk | SPF50 | Grace And Fire USA Inc. | |
| Ultra Violette Sheen Screen Broad Spectrum Hydrating Lip Balm Bejewelled | SPF50 | Grace And Fire USA Inc. | |
| Temazepam | Temazepam | Preferred Pharmaceuticals Inc. | |
| childrens allergy relief | Loratadine | CVS Woonsocket Prescription Center, Incorporated |
Workforce (NPPES)
65,735 new provider enumerations this week; the 10 below lead the list.
| State | New providers | Organizations |
|---|---|---|
| CA | 10,367 | 1,218 |
| TX | 4,434 | 1,065 |
| FL | 4,273 | 1,243 |
| NY | 3,557 | 566 |
| MI | 2,928 | 406 |
| OH | 2,899 | 280 |
| IL | 1,959 | 466 |
| NC | 1,780 | 453 |
| PA | 1,777 | 373 |
| MD | 1,742 | 295 |
Industry Payments (Open Payments)
15,384,974 industry payments this week; the 10 below lead the list.
| Payer | Total (USD) | Payments |
|---|---|---|
| BioNTech SE | 180,558,679 | 164 |
| AbbVie Inc. | 156,382,683 | 1,720,745 |
| Stryker Corporation | 132,155,940 | 162,439 |
| Medtronic, Inc. | 117,649,217 | 342,148 |
| Arthrex, Inc. | 104,199,464 | 49,443 |
| Edge Endo LLC | 91,139,127 | 11 |
| Zimmer Biomet Holdings, Inc. | 83,904,351 | 32,760 |
| Intuitive Surgical, Inc. | 72,225,869 | 116,855 |
| Takeda Pharmaceuticals U.S.A., Inc. | 71,616,187 | 171,595 |
| Advanced Accelerator Applications | 63,931,988 | 167 |
Patents (USPTO, A61)
95 medtech patent grants this week; the 10 below lead the list.
| Assignee | Grants |
|---|---|
| Globus Medical, Inc. | 8 |
| Hytto Pte. Ltd. | 2 |
| Medicrea International | 2 |
| Koninklijke Philips N.V. | 2 |
| Warsaw Orthopedic, Inc. | 2 |
| Neodyne Biosciences, Inc. | 1 |
| GlaxoSmithKline Intellectual Property Development Limited | 1 |
| University of Florida Research Foundation, Incorporated | 1 |
| Intuitive Surgical Operations, Inc. | 1 |
| Universitätsspital Basel | 1 |
Literature (PubMed)
123,818 literature records this week; the 10 below lead the list.
| PMID | Title | Journal | Revised |
|---|---|---|---|
| Recent advances in the molecular biology of growth-hormone secreting human pituitary tumours. | Experimental and clinical endocrinology | ||
| USP26-mediated stabilization of RAD51 promotes endometrial cancer progression and limits ferroptosis. | Frontiers in oncology | ||
| Cyclotorsion as a structural and functional biomarker of ocular and neuroophthalmic diseases. | Acta biochimica Polonica | ||
| Divide or bridge? The heterogeneous effects of digital village participation on rural residents' happiness. | Frontiers in psychology | ||
| Implementation of the World Health Organization's Package of Essential Noncommunicable Disease Interventions: an overview of reviews. | Public health reviews | ||
| Associations between cognitive reserve, iron deposition in the basal ganglia, and cognitive function in mild cognitive impairment. | Frontiers in psychology | ||
| Post-abortion contraceptive uptake among women seeking care for incomplete or induced abortions in Northern Ethiopia: a facility-based cross-sectional study in a humanitarian setting. | Frontiers in public health | ||
| Factors associated with risk perception among school and nursery school teachers concerning potential health effects of exposure to electromagnetic fields. | Frontiers in public health | ||
| ZmEIL2 positively regulates drought tolerance in maize by modulating stomatal movement, hormonal homeostasis, and antioxidant defense. | Frontiers in plant science | ||
| European society for organ transplantation clinical practice guideline on prevention and treatment of chronic lung allograft dysfunction. | Transplant international : official journal of the European Society for Organ Transplantation |
Literature by Subject (MeSH)
210,364 annotated literature records this week; the 10 below lead the list.
| MeSH heading | Articles |
|---|---|
| Humans | 81,392 |
| Female | 41,483 |
| Male | 38,043 |
| Animals | 23,943 |
| Adult | 21,547 |
| Middle Aged | 19,831 |
| Aged | 15,069 |
| Adolescent | 8,431 |
| Young Adult | 8,345 |
| Mice | 8,122 |
Insider Buying (Form 4)
493 open-market insider purchases this week; the 10 below lead the list.
| Ticker | Owner | Traded | Shares | Value (USD) |
|---|---|---|---|---|
| Wang Ching-Dong | 4,545,306 | 10,329,903,316,818 | ||
| Baker Bros. Advisors LP | 1,908,029 | 154,118,138 | ||
| Ault Milton C Iii | 18,000 | 92,412,000 | ||
| Berkshire Hathaway Inc. | 642,821 | 52,441,313 | ||
| N/A | Manufacturers Life Reinsurance Ltd | 2,442,087 | 39,997,992 | |
| Conifer Management, L.L.C. | 133,472 | 32,510,537 | ||
| Nippon Life Insurance Co | 805,782 | 27,519,616 | ||
| Sr One Capital Management, LLC | 1,600,000 | 27,200,000 | ||
| George Simeon | 1,600,000 | 27,200,000 | ||
| N/A | Manulife (International) Ltd | 1,476,118 | 25,998,869 |
Academica Weekly is assembled and published automatically each week. This issue covers 28 September 2026 to 4 October 2026 and was built on 4 October 2026.