Academica Weekly: The Primary Record for the Week Ending 2 August 2026
Trial registrations, clearances, recalls, guidance, safety reports, device listings, and insider filings — assembled from the primary sources with no editor in the loop.
The week of 27 July 2026 to 2 August 2026: 56 Phase 3 trial registrations; 102 Phase 2 trial registrations; 7 recall events; 100 510(k) clearances; 6 FDA guidance documents; 1,575 new Health Canada device licences; 2,644 ARTG device entries; 394 open-market insider purchases.
56 Phase 3 trial registrations
102 Phase 2 trial registrations
7 recall events
100 510(k) clearances
71Phase 1 registrations102Phase 2 registrations56Phase 3 registrations36Phase 4 registrations100510(k) clearances284PMA decisions7recall events6guidance documents352,949adverse event reports333,226device event reports27,811device listings2,644ARTG device entries1,575new device licences553label effective dates58,772new provider enumerations15,384,974industry payments95medtech patent grants96,474literature records394open-market insider purchases
Source Ledger
The latest event date each source holds, measured against its expected publication cadence. A stale source keeps its ledger line and loses its section.
| Source | Latest event | State |
|---|---|---|
| ClinicalTrials.govPhase 1 · Phase 2 · Phase 3 · Phase 4 | 31 July 2026 | Current |
| FDA 510(k) | 17 July 2026 | 16 days behind |
| FDA PMA | 17 July 2026 | Current |
| FDA recalls | 29 July 2026 | Current |
| FDA guidance | 31 July 2026 | Current |
| FAERS | 30 June 2026 | Current |
| MAUDE | 30 June 2026 | Current |
| GUDID | 22 April 2026 | 102 days behind |
| TGA ARTG | 1 August 2026 | Current |
| Health Canada | 31 July 2026 | Current |
| FDA drug labels | 31 July 2026 | Current |
| NPPES | 11 July 2026 | Current |
| Open Payments | 31 December 2024 | 579 days behind |
| USPTO | 10 February 2026 | 173 days behind |
| PubMed | 2 August 2026 | Current |
| SEC Form 4 | 31 July 2026 | Current |
Phase 1 Trials
71 Phase 1 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| A Phase 1b/2a Study of Velinotamig in Adults With Relapsed/Refractory ITP and wAIHA | Cullinan Therapeutics Inc. | 72 | ||
| Safety and Efficacy Study of Sivelestat in Neuromyelitis Optica Spectrum Disorder | Kyushu University | 7 | ||
| A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight | Eli Lilly and Company | 56 | ||
| OLIG2 Inhibitor CT-179 for Recurrent and Newly-diagnosed Glioblastoma | Olivia Newton-John Cancer Research Institute | 54 | ||
| A Study of DS-3939a in Participants With Solid Tumors | Daiichi Sankyo | 400 | ||
| ATR 1072 in Participants With PRKAG2 Syndrome | Atrium Therapeutics | 37 | ||
| Paclitaxel Oral Solution in Triple Neagtive Breast Cancer Neoadjuvant Therapy: A Dose-Finding Study | Liu Shu | 30 | ||
| Paclitaxel Oral Solution in HER2-Positive Breast Cancer Neoadjuvant Therapy: A Dose-Finding Study | Liu Shu | 30 | ||
| GB268 Monotherapy or Combination Therapy for Locally Advanced/Metastatic Breast Cancer (Phase Ib/Ⅱ) | Eddingpharm (Zhuhai) Co., Ltd. | 270 | ||
| A Study to Investigate the Pharmacokinetics, Pharmacodynamics, and Safety of NKF-PEG, and US-Neulasta in Healthy Adult Male Volunteers | Nanjing King-Friend Biochemical Pharmaceutical Co., Ltd. | 202 |
Phase 2 Trials
102 Phase 2 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| Study of Zanubrutinib in Older Patients With Previously Untreated Chronic Lymphocytic Leukemia (CLL) | The Lymphoma Academic Research Organisation | 95 | ||
| Iparomlimab and Tuvonralimab (QL1706) Plus Lenvatinib and Chemotherapy for Extrapulmonary Neuroendocrine Carcinoma | West China Hospital | 92 | ||
| SKB264 Plus KL-A167 in MSI-H/dMMR Advanced Gynecological Malignancies | Peking Union Medical College Hospital | 80 | ||
| A Phase 1b/2a Study of Velinotamig in Adults With Relapsed/Refractory ITP and wAIHA | Cullinan Therapeutics Inc. | 72 | ||
| Safety and Efficacy Study of Sivelestat in Neuromyelitis Optica Spectrum Disorder | Kyushu University | 7 | ||
| Evaluate Ofirnoflast in Adults With Very Low- to Intermediate-risk Myelodysplastic Syndromes Requiring Transfusions | Halia Therapeutics, Inc. | 50 | ||
| Caffeine Consumption and Rate Control in Permanent Atrial FIBrillation: The CAFIB Trial | Hospital Universitario Getafe | 50 | ||
| Retreat-Based Program for Violence-Exposed Women Veterans | VA Office of Research and Development | 48 | ||
| Epcoritamab Plus Venetoclax Plus Ibrutinib in Patients With Chronic Lymphocytic Leukemia With TP53 Alterations | The Lymphoma Academic Research Organisation | 44 | ||
| A Study of DS-3939a in Participants With Solid Tumors | Daiichi Sankyo | 400 |
Phase 3 Trials
56 Phase 3 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| Phase III Study of OT202 in Treating Moderate to Severe Dry Eye | Ocumension Therapeutics (Suzhou) Co., Ltd | 842 | ||
| Modified DHAP Versus Standard DHAP in Relapsed/Refractory Diffused Large B-cell Lymphoma. | King Edward Medical University | 74 | ||
| Evaluation of the Efficacy and Safety of Tirzepatide, a Dual GLP-1/GIP Agonist, on Functional Capacity in Reduced Ejection Fraction Heart Failure Patients With Obesity | Shahid Beheshti University of Medical Sciences | 60 | ||
| Caffeine Consumption and Rate Control in Permanent Atrial FIBrillation: The CAFIB Trial | Hospital Universitario Getafe | 50 | ||
| Comparison of Efficacy and Safety Profile Between Moisturizers Containing a Combination of 5% Hydro-Urea, Ceramide, With MultiVesicular Emulsion Technology and Petrolatum on Dry Sk | Dr. dr. Lili Legiawati, SpKK(K) | 48 | ||
| A Study of YL201 in Combination With Serplulimab in Participants With Treatment-naïve Extensive-stage Small Cell Lung Cancer | MediLink Therapeutics (Suzhou) Co., Ltd. | 442 | ||
| Study to Evaluate the effIcacy and Safety of Abelacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral Anticoagulation | Novartis Pharmaceuticals | 2,500 | ||
| A Study Comparing Treatment With Teclistamab and Talquetamab Versus Daratumumab and Lenalidomide in Patients With Multiple Myeloma After Stem Cell Transplant Who Still Have Detecta | Polish Myeloma Consortium | 248 | ||
| A Study Comparing BL-B01D1 in Combination With PD-1/VEGF Bispecific Antibody Versus Chemotherapy in Combination With PD-1/VEGF Bispecific Antibody in First-line Patients With Local | Sichuan Baili Pharmaceutical Co., Ltd. | 200 | ||
| Osimertinib With or Without Primary Lung Tumor Resection for EGFR-Mutant Oligometastatic Non-Small Cell Lung Cancer | National Taiwan University Hospital | 154 |
Phase 4 Trials
36 Phase 4 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| SAFE (Self-Administration of Flumist to ImprovE Uptake: A Household-Based Cluster Randomized Trial) | McMaster University | 966 | ||
| Effect of Intraoperative Tetracycline on Postoperative Pain After Mandibular Molar Extraction | CMH Lahore Medical College and Institute of Dentistry | 74 | ||
| The Effect of Bilateral Intermediate Cervical Plexus Block on the Surgical Stress Response Following Total Thyroidectomy | University Hospital Dubrava | 48 | ||
| A Postmarketing Open-Label Study to Assess Residual Levonorgestrel (LNG) and Ethinyl Estradiol (EE) Content of TWIRLA® (Levonorgestrel and Ethinyl Estradiol) Transdermal System | Insud Pharma | 28 | ||
| A Study on the Preventive Effect of Electroacupuncture Combined With Dexmedetomidine in Post-stroke Depression | Min Su | 231 | ||
| Oral Versus Intravenous Tranexamic Acid in Off-Pump Coronary Artery Bypass Surgery | Clinique Saint-Luc | 160 | ||
| Low-dose Versus Standard-dose Remimazolam for Prevention of Emergence Agitation After Nasal Surgery | Jeju National University School of Medicine | 138 | ||
| Routine Antiemetic Prophylaxis for Nonfasted Parturients Undergoing Cesarean Sections Under Spinal Anesthesia | Sanliurfa Education and Research Hospital | 100 | ||
| PATHS-T2D: A Recall-by-Genotype Study of Physiologic and Pharmacologic Responses | Massachusetts General Hospital | 100 | ||
| Efficacy of Melatonin Treatment on Sleep Quality Improvement in Inflammatory Bowel Disease Patients With Clinical Remission: A Randomized Double-Blind Placebo-Controlled Trial | Mahidol University | 90 |
510(k) Clearances
100 510(k) clearances this week; the 10 below lead the list.
| K number | Device | Applicant | Class | Decision |
|---|---|---|---|---|
| Catalyft PL Expandable Interbody System | Medtronic Sofamor Danek USA, Inc. | 2 | ||
| Zeiss Clinic 360 | Carl Zeiss Meditec, AG | 2 | ||
| Drivewire 35 Guidewire | Rapid Medical Ltd. | 2 | ||
| Cubresa BrainPET | Cubresa, Inc. | 2 | ||
| SportSuite Vision Software | Stryker Endoscopy | |||
| Diode laser hair removal machine (QDTM-04) | Beijing Nubway S&T Co., Ltd. | 2 | ||
| Tritanium® C Anterior Cervical Cage; Tritanium® PL Cage; Tritanium® TL Curved Posterior Lumbar Cage; Aero® -C Cervical Cage System; AVS® Anchor-C Cervical | Stryker Spine | 2 | ||
| Dental Zirconia Blank & Coloring Liquid | Hunan Qinghao Puzhong Technology Co., Ltd. | 2 | ||
| Natural Cycles | Natural Cycles Nordic AB | 2 | ||
| BIOFIRE® FILMARRAY® Tropical Fever Panel Control Kit | Biofire Defense, LLC | 2 |
PMA Approvals
284 PMA decisions this week; the 10 below lead the list.
| PMA | Device | Applicant | Decision |
|---|---|---|---|
| Edwards Crimper: 9600CR | Edwards Lifesciences, LLC | ||
| Spinal Cord Stimulation (SCS) Implantable Pulse Generator (IPG) | Abbott Medical | ||
| Edwards SAPIEN 3 Pulmonic Delivery System: 9630PL29 | Edwards Lifesciences, LLC | ||
| Deep Brain Stimulation (DBS) Implantable Pulse Generator (IPG) | Abbott Medical | ||
| HeartMate 3 Left Ventricular Assist System (LVAS) | Abbott Medical | ||
| Percepta Bipolar CRT-P, Percepta Quadripolar CRT-P, Serena Bipolar CRT-P, Serena Quadripolar CRT-P, Solara Bipolar CRT-P | Medtronic, Inc. | ||
| AED 3; CPR Uni-Padz | ZOLL Medical Corporation | ||
| Amplia MRI CRT-D, Amplia MRI Quad CRT-D, Brava CRT-D, Brava Quad CRT-D, Claria MRI CRT-D, Claria MRI Quad CRT-D, Cobalt | Medtronic Cardiac Rhythm Disease Management | ||
| Evera S DR ICD, Evera S VR ICD, Evera XT VR ICD, Mirro MRI DR ICD, Mirro MRI VR ICD, Primo MRI DR ICD, Primo MRI VR ICD, | Medtronic Cardiac Rhythm Disease Management | ||
| Vercise Deep Brain Stimulation (DBS) Systems | Boston Scientific Corp |
Recalls
7 recall events this week.
| Firm | Product | Reason | Catalog rows | Posted |
|---|---|---|---|---|
| Instrumentation Laboratory | Brand Name: GEM Premier 7000 with iQM3 Product Name: GEM Premier 7000 with iQM3 Model/Catalog Number: 00000015279 Intelligent Quality Management 3 (iQM3) is used as the quality control (QC) and a | BCR wands that received a configuration update (released under Service Information No. 2026-07 on or after April 8, 2026) may assign patient results to an incorrect patient ID. The root cause is a race condition introduced when the "price c | 6 | |
| Stryker GmbH | Stryker Hoffmann II Connecting Rod Micro 3 x 60mm. Catalog Number: 50796060. | Potential cracking of the Hoffmann II Carbon Connecting Rods following cleaning and sterilization. | 7 | |
| IsoTis OrthoBiologics, Inc. | OsteoBallast, 45 x 17.5 mm (SeaSpine Brand), REF: 56800095. Ballast, 45 x 17.5 mm (IsoTis Brand), REF: 02-8000-095 | Demineralized bone matrix (DBM) in resorbable mesh indicated for use with autograft as a bone graft extender in the posterolateral spine and pelvis, were filled with approx. 4.5 cc DBM (fill for 45 11 mm configuration) instead of approx. 7 | 1 | |
| ResMed Ltd. | Resmed Astral 100/150 Resmed Astral 100/50 is a ventilator system that provides continuous or intermittent ventilatory support for patients weighing more than 11lb (5kg) who require mechanical vent | Due to a Supercapacitor electrolyte leakage on Printed Circuit Board Assembly (PCBA) may damage the charger chip, causing fail-safe state and interruption of ventilation therapy. | 1 | |
| Windstone Medical Packaging, Inc. | AMS ALIGNED MEDICAL SOLUTIONS medical convenience kits labeled as: 1) Nerve Block Tray - RX, Part Number AMS13975A; 2) Universal Block Tray- RX, Part Number AMS2009; 3) Nerve Block Tray - RX, Part | Windstone Medical Packaging issued a recall for specific item(s) and lot(s) of Aligned Medical Solutions (AMS) convenience kits containing Elevaris Lidocaine HCl injection USP. Elevaris Medical Devices Inc. recalled the Lidocaine HCl injec | 8 | |
| Medtronic Perfusion Systems | EOPA Elongated One-Piece Arterial Cannula DIL TIP 22FR, intended for use with cardiopulmonary bypass as an arterial return cannula, Model Number 77622 | Medtronic received reports of pinhole leaks in the wire-wound body of 22 Fr EOPA 3D Arterial Cannulae and EOPA Elongated One-Piece Arterial Cannulae used during cardiopulmonary bypass procedures. | 6 | |
| Philips Medical Systems | Brilliance iCT Brilliance iCT Upgrades Brilliance iCT SP Brilliance CT 64 Channel CT6000 Brilliance 64 Upgrades | The clinical CT scan may not automatically trigger after the Bolus Tracking scan and may need to be triggered manually. Additional Bolus Tracking shots may occur. This may result in the clinical acquisition being inadequate for diagnosis, c | 3 |
FDA Guidance
6 guidance documents this week.
| Title | Topic | Issued |
|---|---|---|
| Biosimilar and Interchangeable Biosimilar Products: Considerations for Container Closure Systems and Device Constituent Parts | Biosimilars; Drugs; Center for Drug Evaluation and Research; Draft | |
| Assessing Adhesion With Transdermal and Topical Delivery Systems for ANDAs: Guidance for Industry | Drug Competition Action Plan, Generic Drugs; Drugs; Center for Drug Evaluation and Research; Final | |
| Assessing the Irritation and Sensitization Potential of Transdermal and Topical Delivery Systems for ANDAs: Draft Guidance for Industry | Drug Competition Action Plan, Generic Drugs; Drugs; Center for Drug Evaluation and Research; Draft | |
| Cancer Clinical Trial Eligibility Criteria: Washout Periods and Concomitant Medications: Guidance for Industry, IRBs, and Clinical Investigators | Clinical Trials,; Biologics, Drugs; Office of the Commissioner; Final | |
| Cancer Clinical Trial Eligibility Criteria: Performance Status: Guidance for Industry, IRBs, and Clinical Investigators | Clinical Trials,; Biologics, Drugs; Office of the Commissioner; Final | |
| Cancer Clinical Trial Eligibility Criteria: Laboratory Values: Guidance for Industry, IRBs, and Clinical Investigators | Clinical Trials,; Biologics, Drugs; Office of the Commissioner; Final |
Drug Safety Reports (FAERS)
352,949 adverse event reports this week; the 10 below lead the list.
| Reaction | Reports |
|---|---|
| Off label use | 19,437 |
| Drug ineffective | 17,826 |
| Nausea | 13,583 |
| Product dose omission issue | 12,230 |
| Diarrhoea | 12,101 |
| Death | 11,969 |
| Fatigue | 11,899 |
| Pruritus | 10,348 |
| Headache | 9,032 |
| Meningioma | 8,392 |
Device Safety Reports (MAUDE)
333,226 device event reports this week; the 10 below lead the list.
| Brand | Manufacturer | Events |
|---|---|---|
| FreeStyle Libre 3 | 26,773 | |
| Dexcom G7 Continuous Glucose Monitoring System | 16,748 | |
| FreeStyle Libre 3 Plus | 13,218 | |
| t:slim X2 Insulin Pump with Control-IQ Technology | 10,423 | |
| DreamStation Auto CPAP | 8,072 | |
| CareLink SmartSync Common App iOS | 7,354 | |
| Inset Guard | 7,073 | |
| t:slim X2 Insulin Pump with Control-IQ+ Technology | 5,375 | |
| Quick Set | 4,518 | |
| MiniMed 780G US System BLE Connect 3.0 mg/dL | 4,366 |
Device Listings (GUDID)
27,811 device listings this week; the 10 below lead the list.
| Brand | Company | GMDN | Published |
|---|---|---|---|
| Melpex | Melpex Beauty Instruments | General-purpose surgical scissors, reusable | |
| Anyplus Peek Cage System | GS Medical Co., Ltd. | Polymeric spinal interbody fusion cage | |
| Wrap Around Quick Release | Shielding International Inc. | Radiation shielding apron | |
| Anyplus Peek Cage System | GS Medical Co., Ltd. | Polymeric spinal interbody fusion cage | |
| ProCure | Twin Med, LLC | Wound hydrogel dressing, non-antimicrobial | |
| TrellOss®-MCP | Nexxt Spine, LLC | General internal orthopaedic fixation system implantation kit | |
| Golden Isles Pedicle Screw System | Intelivation, LLC | Orthopaedic implantation sleeve, reusable | |
| TrellOss®-MCP | Nexxt Spine, LLC | Spinal fixation plate, non-bioabsorbable | |
| K2-HF SHOULDER, SH-6 T powder, 20g. | Yeti Dentalprodukte GmbH | Dental appliance fabrication material, ceramic | |
| Wrap Around Quick Release | Shielding International Inc. | Radiation shielding apron |
Australia (TGA ARTG)
2,644 ARTG device entries this week; the 10 below lead the list.
| Brand | Manufacturer | Sponsor | Class | Effective |
|---|---|---|---|---|
| Glaukos® iprism® S | Katena Products Inc | RQSolutions Medical Devices Distribution Support | Class 1 Sterile | |
| Glaukos® iprism® S | Katena Products Inc | RQSolutions Medical Devices Distribution Support | Class 1 Sterile | |
| KXL® System | Avedro a Glaukos company | RQSolutions Medical Devices Distribution Support | Class IIa | |
| Secureflex HF Surgical Gonio Lens | Ocular Instruments Inc | RQSolutions Medical Devices Distribution Support | Class 1 Sterile | |
| Boost Goggles™ | Avedro a Glaukos company | RQSolutions Medical Devices Distribution Support | Class 1 | |
| Glaukos® iprism® SX | Katena Products Inc | RQSolutions Medical Devices Distribution Support | Class 1 Sterile | |
| Benchmark Intracranial Access System | Penumbra Inc | Penumbra Neuro Australia Pty Ltd | Class III | |
| Benchmark Intracranial Access System | Penumbra Inc | Penumbra Neuro Australia Pty Ltd | Class III | |
| JustRight Surgical | Hologic Inc | Optimed Technologies Pty Ltd | Class IIb | |
| IV CATHETER for Single Use Pen Type | Zhejiang Kindly Medical Devices Co Ltd. | Syrinx Systems Pty Ltd | Class IIb |
Canada (Health Canada MDALL)
1,575 new device licences this week; the 10 below lead the list.
| Device | Company | Class | Licensed |
|---|---|---|---|
| Supersoft Infant Nasal Cannula with Crush Resistant Tubing and Standard Connector | Medline Industries, LP | 2 | |
| Set Zirkonzahn Multi Unit Abutment 17(Degree) L10 Type 2 for Zimmer Dental Tapered Screw-Vent | Zirkonzahn SRL | 3 | |
| Set Narrow Ti-Base Non Hex for Astra Tech Implant System Osseospeed | Zirkonzahn SRL | 3 | |
| Set Narrow Ti-Base Non Hex for Astra Tech Implant System Ev/Uniabutment Ev | Zirkonzahn SRL | 3 | |
| Set Narrow Ti-Base Non Hex for Anthogyr Axiom Reg / Px | Zirkonzahn SRL | 3 | |
| Set Narrow Ti-Base Hex for Zimmer Dental Tapered Screw-Vent 3.5 | Zirkonzahn SRL | 3 | |
| Set Narrow Ti-Base Hex for Zimmer Dental Spline Implant System 3.25 | Zirkonzahn SRL | 3 | |
| Set Narrow Ti-Base Hex for Zimmer Dental Eztetic Implant System Np | Zirkonzahn SRL | 3 | |
| Set Narrow Ti-Base Hex for Straumann Tissue Level (Standard Plus Narrow Neck Crossfit / Synocta) Nnc 3.5 | Zirkonzahn SRL | 3 | |
| Set Narrow Ti-Base Hex for Straumann Bone Level | Zirkonzahn SRL | 3 |
Drug Labels
553 label effective dates this week; the 10 below lead the list.
| Brand | Generic | Manufacturer | Effective |
|---|---|---|---|
| Sugammadex | Sugammadex | Lupin Pharmaceuticals, Inc. | |
| Icy Hot Original Nighttime Recovery Pain Relief No Mess Roll On | Menthol | Chattem, Inc. | |
| Dehydrated Alcohol | Alcohol | Avenacy, LLC | |
| Valsartan | Valsartan | ScieGen Pharmaceuticals, INC. | |
| Clevariel Minoxidil Hair Growth Serum | Minoxidil | Guangzhou Ariel Medical Technology Co., Ltd. | |
| Famotidine | Famotidine | PD-Rx Pharmaceuticals, Inc. | |
| Ustekinumab-aekn | Ustekinumab-Aekn | Teva Pharmaceuticals USA, Inc. | |
| Rocuronium Bromide | Rocuronium Bromide | Shandong New Time Pharmaceutical Co., Ltd. | |
| Gabapentin | Gabapentin | RemedyRepack Inc. | |
| Ozempic | Semaglutide | A-S Medication Solutions |
Workforce (NPPES)
58,772 new provider enumerations this week; the 10 below lead the list.
| State | New providers | Organizations |
|---|---|---|
| CA | 7,952 | 1,185 |
| TX | 4,174 | 1,146 |
| FL | 3,956 | 1,137 |
| NY | 2,967 | 489 |
| MI | 2,564 | 387 |
| OH | 2,470 | 418 |
| IL | 1,973 | 385 |
| PA | 1,815 | 295 |
| MD | 1,805 | 393 |
| NC | 1,788 | 433 |
Industry Payments (Open Payments)
15,384,974 industry payments this week; the 10 below lead the list.
| Payer | Total (USD) | Payments |
|---|---|---|
| BioNTech SE | 180,558,679 | 164 |
| AbbVie Inc. | 156,382,683 | 1,720,745 |
| Stryker Corporation | 132,155,940 | 162,439 |
| Medtronic, Inc. | 117,649,217 | 342,148 |
| Arthrex, Inc. | 104,199,464 | 49,443 |
| Edge Endo LLC | 91,139,127 | 11 |
| Zimmer Biomet Holdings, Inc. | 83,904,351 | 32,760 |
| Intuitive Surgical, Inc. | 72,225,869 | 116,855 |
| Takeda Pharmaceuticals U.S.A., Inc. | 71,616,187 | 171,595 |
| Advanced Accelerator Applications | 63,931,988 | 167 |
Patents (USPTO, A61)
95 medtech patent grants this week; the 10 below lead the list.
| Assignee | Grants |
|---|---|
| Globus Medical, Inc. | 8 |
| Hytto Pte. Ltd. | 2 |
| Medicrea International | 2 |
| Koninklijke Philips N.V. | 2 |
| Warsaw Orthopedic, Inc. | 2 |
| Neodyne Biosciences, Inc. | 1 |
| GlaxoSmithKline Intellectual Property Development Limited | 1 |
| University of Florida Research Foundation, Incorporated | 1 |
| Intuitive Surgical Operations, Inc. | 1 |
| Universitätsspital Basel | 1 |
Literature (PubMed)
96,474 literature records this week; the 10 below lead the list.
| PMID | Title | Journal | Revised |
|---|---|---|---|
| Differential bone marrow aspirate DNA yields from commercial extraction kits. | Leukemia | ||
| Imitation performance in toddlers with autism and those with other developmental disorders. | Journal of child psychology and psychiatry, and allied disciplines | ||
| The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport. | Journal of cell science | ||
| MAPK signaling contributes to rotaviral-induced cholangiocyte injury and viral replication. | Surgery | ||
| The role of myeloperoxidase in the pathogenesis of postoperative adhesions. | Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society | ||
| Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. | Nature genetics | ||
| Differences in the association between sickness absence and long-term sub-optimal health by occupational position: a 14-year follow-up in the GAZEL cohort. | Occupational and environmental medicine | ||
| Polymer folding: ABC of molecular origami. | Nature chemistry | ||
| Longitudinal changes in Scores on the Autism Diagnostic Interview--Revised (ADI-R) in pre-school children with autism: Implications for diagnostic classification and symptom stability. | Autism : the international journal of research and practice | ||
| Antipsychotic medication for early episode schizophrenia. | The Cochrane database of systematic reviews |
Literature by Subject (MeSH)
96,474 annotated literature records this week; the 10 below lead the list.
| MeSH heading | Articles |
|---|---|
| Humans | 42,779 |
| Female | 24,089 |
| Male | 22,088 |
| Middle Aged | 13,073 |
| Adult | 13,034 |
| Animals | 9,730 |
| Aged | 9,647 |
| Young Adult | 4,881 |
| Retrospective Studies | 4,504 |
| Adolescent | 4,227 |
Insider Buying (Form 4)
394 open-market insider purchases this week; the 10 below lead the list.
| Ticker | Owner | Traded | Shares | Value (USD) |
|---|---|---|---|---|
| Frangou Angeliki | 3,393 | 2,538,367,767 | ||
| NONE | Abu Dhabi Investment Authority | 8,740,776 | 125,000,087 | |
| N/A | TPG GP A, LLC | 1,984,182 | 50,000,000 | |
| Aghazadeh Behzad | 2,383,333 | 36,115,495 | ||
| NONE | MSD Capital, L.P. | 1,274,194 | 30,950,172 | |
| Huang Jack Jiajia | 1,495,980 | 24,863,188 | ||
| NONE | Abu Dhabi Investment Authority | 932,917 | 22,935,759 | |
| Huang Jack Jiajia | 1,264,320 | 19,929,629 | ||
| OrbiMed Advisors LLC | 1,000,000 | 15,000,000 | ||
| Gordon Carl L | 1,000,000 | 15,000,000 |
Academica Weekly is assembled and published automatically each week. This issue covers 27 July 2026 to 2 August 2026 and was built on 3 August 2026.