Academica Weekly: The Primary Record for the Week Ending 12 July 2026
Trial registrations, clearances, recalls, guidance, safety reports, device listings, and insider filings — assembled from the primary sources with no editor in the loop.
The week of 6 July 2026 to 12 July 2026: 50 Phase 3 trial registrations; 113 Phase 2 trial registrations; 22 recall events; 52 510(k) clearances; 164 new Health Canada device licences; 5,186 ARTG device entries; 872 open-market insider purchases.
50 Phase 3 trial registrations
113 Phase 2 trial registrations
22 recall events
52 510(k) clearances
84Phase 1 registrations113Phase 2 registrations50Phase 3 registrations51Phase 4 registrations52510(k) clearances39PMA decisions22recall events352,949adverse event reports333,226device event reports27,811device listings5,186ARTG device entries164new device licences925label effective dates13,639new provider enumerations15,384,974industry payments95medtech patent grants159,428literature records872open-market insider purchases
Source Ledger
The latest event date each source holds, measured against its expected publication cadence. A stale source keeps its ledger line and loses its section.
| Source | Latest event | State |
|---|---|---|
| ClinicalTrials.govPhase 1 · Phase 2 · Phase 3 · Phase 4 | 31 July 2026 | Current |
| FDA 510(k) | 17 July 2026 | Current |
| FDA PMA | 17 July 2026 | Current |
| FDA recalls | 29 July 2026 | Current |
| FDA guidance | 31 July 2026 | Current |
| FAERS | 30 June 2026 | Current |
| MAUDE | 30 June 2026 | Current |
| GUDID | 22 April 2026 | 81 days behind |
| TGA ARTG | 1 August 2026 | Current |
| Health Canada | 31 July 2026 | Current |
| FDA drug labels | 12 July 2026 | Current |
| NPPES | 11 July 2026 | Current |
| Open Payments | 31 December 2024 | 558 days behind |
| USPTO | 10 February 2026 | 152 days behind |
| PubMed | 2 August 2026 | Current |
| SEC Form 4 | 31 July 2026 | Current |
Phase 1 Trials
84 Phase 1 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| A Study of LM-364 as a Single Agent or in Combination With Anti-tumor Therapy in Patients With Advanced Solid Tumors | LaNova Medicines Limited | 90 | ||
| Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 Tablet | Reistone Biopharma Company Limited | 40 | ||
| Study of ChoironeX GalKO Porcine Thymokidney Xenotransplantation in End-Stage Renal Disease | Xeno Holdings (US), LLC dba ChoironeX | 4 | ||
| QT Interval Effects Study of Oral FXS5626 Tablets | Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | 28 | ||
| A Phase 1 Study to Evaluate the Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of HSK46256 in Patients With Advanced Solid Tumors | Haisco Pharmaceutical Group Co., Ltd. | 275 | ||
| Rituximab for Treatment of Checkpoint Inhibitor Induced Immune-related Adverse Events | Inge Marie Svane | 25 | ||
| An Exploratory Study of Obinutuzumab β in the Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy | Zhongming Qiu | 24 | ||
| EWSR1 Immunotherapy in Ewing Sarcoma and DSRCT | Rabi Hanna | 24 | ||
| A Phase I Clinical Trial to Evaluate the Pharmacokinetic and Safety of Ammoxetine Hydrochloride Enteric-Coated Tablets in Participants With Mild Hepatic Impairment, Moderate Hepati | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | 24 | ||
| A Phase 1 Study to Evaluate the Safety, Reactogenicity and Immunogenicity of YKYY025 Injection | Beijing Youcare Kechuang Pharmaceutical Technology Co., Ltd. | 180 |
Phase 2 Trials
113 Phase 2 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| Lemborexant Use for Cognition Improvement in Postoperative Delirium in Elderly Patients: A Randomized Controlled Trial | Beijing Tiantan Hospital | 992 | ||
| A Study of LM-364 as a Single Agent or in Combination With Anti-tumor Therapy in Patients With Advanced Solid Tumors | LaNova Medicines Limited | 90 | ||
| Study of YKST02 in Adults With Relapsed or Refractory Multiple Myeloma | Excyte Biopharma Ltd | 64 | ||
| A Multicenter, Single Arm Study to Evaluate the Preliminary Efficacy and Safety Profile of Inavolisib in Previously Treated Pancreatic Ductal Adenocarcinoma Patients | Fudan University | 62 | ||
| Lumacaftor Yields Reversal of Impaired Cerebral Blood Flow in Heart Failure Patients | Qanatpharma AG | 60 | ||
| A Study of MZE782 in Adults With PKU | Maze Therapeutics | 38 | ||
| Trial of Therapies With IT cDC1s Combined w/ IT Trastuzamab for Her+ or IT Nivolumab for Her- BC LMD | H. Lee Moffitt Cancer Center and Research Institute | 30 | ||
| Bepirovirsen Liver Biopsy Study | National University Health System, Singapore | 30 | ||
| A Study of SYH2070 Injection in Participants With Mixed Hyperlipidemia | CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. | 240 | ||
| An Exploratory Study of Obinutuzumab β in the Treatment of Chronic Inflammatory Demyelinating Polyradiculoneuropathy | Zhongming Qiu | 24 |
Phase 3 Trials
50 Phase 3 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| Mo-Rez in First- Line (1L) Maintenance Treatment of Non- Homologous Recombination Deficient Ovarian Cancer (HRd OC) [BEHOLD-Ovarian03] | GlaxoSmithKline | 720 | ||
| Micronutrient Enhancement for Development and Health in Adolescents - The MEDHA Study | Johns Hopkins Bloomberg School of Public Health | 3,000 | ||
| Safety and Efficacy Evaluation of SMZ1 With Ranibizumab in Patients With Neovascular Age-related Macular Degeneration Without Polypoidal Choroidal Vasculopathy | SANGMYUNG innovation | 266 | ||
| Effects, Metabolic Mechanisms and Predictors of Response to Acupuncture in Treating Psychoneurological Symptoms Among Breast Cancer Survivors | University of Illinois at Chicago | 252 | ||
| Efficacy and Safety Study of Tunodafil Hydrochloride Tablets in Erectile Dysfunction | Yangtze River Pharmaceutical Group Co., Ltd. | 780 | ||
| A Study of TACE in Combination With SHR-8068, Adebrelimab, and Bevacizumab Versus TACE in Participants With Incurable Hepatocellular Carcinoma | Suzhou Suncadia Biopharmaceuticals Co., Ltd. | 690 | ||
| Intrauterine G-CSF Infusion for Thin Endometrium | Nanjing University | 620 | ||
| Single-Dose vs. Divided-Dose G-CSF for Stem Cell Mobilization in Healthy Allogeneic Donors | First Affiliated Hospital of Zhejiang University | 560 | ||
| A Phase III Study to Evaluate the Efficacy and Safety of of DR10624 in Subjects With Severe Hypertriglyceridemia | Zhejiang Doer Biologics Co., Ltd. | 480 | ||
| Sintilimab Versus Mitomycin in Combination With Capecitabine and IMRT for Limited-stage Anal Squamous Cell Carcinoma | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | 350 |
Phase 4 Trials
51 Phase 4 registrations this week; the 10 below lead the list.
| NCT | Study | Sponsor | Enrollment | Posted |
|---|---|---|---|---|
| Efficacy of Nonsteroidal Anti-Inflammatory Drugs for the Prevention of Cystoid Macular Edema Following Cataract Phacoemulsification | Pomeranian Medical University Szczecin | 88 | ||
| Efficacy and Tolerability of a Simethicone-containing Evacuating Solution for Colorectal Cancer Screening Colonoscopy | Fundacion Clinic per a la Recerca Biomédica | 818 | ||
| Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for Melasma | Sameh Sarsik | 80 | ||
| Olaparib+Trastuzumab+Pertuzumab Neoadjuvant for Elderly HER2+ Breast Cancer | Wen-Ming Cao | 45 | ||
| Effect of Different Resin Composite Packing Techniques on Pulp Condition (Randomized Clinical Trial) | October 6 University | 30 | ||
| A Prospective Longitudinal Analysis of Faricimab (Vabysmo 6mg) For Choroidal Neovascularization in Presumed Ocular Histoplasmosis Syndrome | Cincinnati Eye Institute, Southwest Ohio | 25 | ||
| A Multicenter, Prospective, Randomized Controlled Clinical Trial Assessing the Efficacy of a Novel Cellular, Acellular, Matrix-like Product (CAMP) Plus Standard of Care Versus Stan | BioLab Holdings | 160 | ||
| Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis | Eidos Therapeutics, a BridgeBio company | 150 | ||
| Ciprofol vs Propofol for Hemodynamic Stability in Patients Having General Anesthesia for Endovascular Thrombectomy After Ischemic Stroke | RenJi Hospital | 124 | ||
| Ultra-Long GnRH-a Pretreatment for FET Outcomes in Patients With Deep Infiltrating Endometriosis | Li-jun Ding | 120 |
510(k) Clearances
52 510(k) clearances this week; the 10 below lead the list.
| K number | Device | Applicant | Class | Decision |
|---|---|---|---|---|
| Minnesota Four-Lumen Esophagogastric Tamponade Tube - 18 French (0092220); Blakemore Esophageal-Nasogastric Tube - 20 French (0092100); Blakemore Esophageal-Nas | C.R. Bard, Inc. | 2 | ||
| LungFlow Airway Catheter | Free Flow Medical, Inc. | 2 | ||
| ClearSafe Closed System | MedSource Labs, LLC | 2 | ||
| Omnifit® 20° Series I Insert;Omnifit® Crossfire® 10° Series II Insert; Constrained Acetabular Insert; Trident® Crossfire® 0° Polyethylene Insert; Triden | Howmedica Osteonics Corp., Dba Stryker Orthopaedics | 2 | ||
| NYES Tuff Cuff L3 Disposable Gowns | New York Embroidery Studio | 2 | ||
| SedLine Sedation Monitor | Masimo Corporation | 2 | ||
| Cochlear Osia® 3(I) Sound Processor;Cochlear Osia® 3 Sound Processor;Cochlear Osia® 3 Charger;Cochlear Osia® 3 Aqua+;Cochlear Osia® Fitting Softw | Cochlear Americas | 2 | ||
| AI Contouring (VA10A) | Varian Medical Systems | 2 | ||
| WallFlex Esophageal Stent System;Agile Esophageal Over-the-Wire (OTW) Stent System | Boston Scientific Corporation | 2 | ||
| Capenergy C Equipments RF C200 and C400 Drakarian | Capenergy Medical S.L. | 2 |
PMA Approvals
39 PMA decisions this week; the 10 below lead the list.
| PMA | Device | Applicant | Decision |
|---|---|---|---|
| Precision Spinal Cord Stimulator (SCS) Systems | Boston Scientific Corp | ||
| EverFlex Self-expanding Peripheral Stent System | Medtronic Vascular, Inc. | ||
| Vercise Deep Brain Stimulation (DBS) Systems | Boston Scientific Corp | ||
| FARAPULSE Pulsed Field Ablation System (FARAPULSE) | Farapulse, Inc. | ||
| Model 3150 Implantable Pulse Generator (IPG) | Inspire Medical Systems | ||
| HexaGen RF Generator Software and Remote | Medtronic, Inc. | ||
| Volt PFA System | Abbott Medical | ||
| Protege GPS Self-expanding Peripheral Stent System | Medtronic Vascular, Inc. | ||
| Trilogy Transcatheter Heart Valve System | JenaValve Technology, Inc. | ||
| Belotero® Intense (+) Lidocaine | Merz North America, Inc. |
Recalls
22 recall events this week; the 10 below lead the list.
| Firm | Product | Reason | Catalog rows | Posted |
|---|---|---|---|---|
| ICU Medical, Inc. | ICU Medical Plum Duo Infusion Pump, v1.2.3: 1) Item Number 400020401 and 2) Item Number 400020403; infusion pump | In a specific scenario, the pump will not decrement the Volume to be Infused (VTBI) displayed on the Delivery screen and may deliver up to twice the VTBI at the programmed rate. | 2 | |
| Intuitive Surgical, Inc. | da Vinci SP Instrument Arm Drape, SP, 1-PACK, Part Number: 430013-13, 430013-15 | Robotic-assisted surgical system arm drapes may detach from the instrument arm due to an issue involving the drape rings located at the top of the product, which may expose a section of instrument arm, which may result in procedure delay or | 1 | |
| Argon Medical Devices, Inc | General Biospy Tray, REF: GUTS1000 | Kits containing Lidocaine HCL Injection USP 1% 10mg/mL 5mL ampules subject to another recall recalled due to not meeting release criteria for sterility. | 6 | |
| Oscor Inc. | Abiomed REF: 0052-3006, Introducer Kit for Impella Hemostatic Peel Away Introducer System with Infusion Sideport, 23F. heart pump and accessories. | Due to manufacturing issues, there is a potential for the 14Fr and 23Fr introducer sheaths to leak from the sidearm, under the sheath cap, and along the hub score lines in the hub region. | 3 | |
| Abiomed, Inc. | ABIOMED Impella CP Introducer Kit 14 Fr, 13 cm, Pump Set Code 0052-0038, containing Kit, 14Fr Introducer, 13cm, Long Taper, Introducer Product Code 0052-3052. heart pump and accessories | A potential for introducer sheath leakage from under the sheath cap and along the hub score lines, identified in 14Fr and 23Fr Introducers. These manufacturing issues are not visually detectable by the user, and 14Fr or 23Fr Introducers are | 13 | |
| Olympus Corporation of the Americas | Olympus Glass Body for 194 Ellik Evacuator. Model Number: 190A. | Some sterilization parameters included in the IFU may not consistently render the devices adequately sterile and therefore should no longer be used to sterilize the devices. | 4 | |
| Boston Scientific Corporation | Rapid Refill Continuous Injection System, UPN M00566001 | Devices contain recalled Medline Namic Angiographic Control Syringe with Rotating Adaptor. There is a risk of syringe loosening or disconnecting from the manifold, resulting in loose connection or complete disconnection. May lead to difficu | 1 | |
| Elekta, Inc. | Brand Name: Brachytherapy Applicator Product Name: Advanced Gynecological Applicator Product Description: The intended use of the Advanced Gynecological Applicator is intracavitary brachytherapy for c | Due to safety concerns regarding the detachment of the tip of the intrauterine tube (IU tube) that may remain within a patient. | 3 | |
| Wallac Oy | GSP Neonatal GALT Kit. Product Codes: 3303-001U, 3303-0010. in vitro diagnostic. Used in FLUORESCENT PROC. (QUAL), GALACTOSE-1-PHOSPHATE URIDYL TRANSFERASE. | Reduction in the on-board stability of the GSP GALT assay. This may increase the likelihood of run-QC failures and consequently delay the reporting of patient results. | 1 | |
| Think Surgical, Inc. | TMINI Femur Tracking Array REF 109003 UDI-DI code: M9461090030 TMINI Tibia Tracking Array REF 109004 UDI-DI code: M9461090040 TMINI Miniature Robotic System is indicated as a stereotaxic instrumenta | Due to manufacturing/design issue where the knob on the tracking array may loosen causing potential misalignment of the array. | 1 |
Drug Safety Reports (FAERS)
352,949 adverse event reports this week; the 10 below lead the list.
| Reaction | Reports |
|---|---|
| Off label use | 19,437 |
| Drug ineffective | 17,826 |
| Nausea | 13,583 |
| Product dose omission issue | 12,230 |
| Diarrhoea | 12,101 |
| Death | 11,969 |
| Fatigue | 11,899 |
| Pruritus | 10,348 |
| Headache | 9,032 |
| Meningioma | 8,392 |
Device Safety Reports (MAUDE)
333,226 device event reports this week; the 10 below lead the list.
| Brand | Manufacturer | Events |
|---|---|---|
| FreeStyle Libre 3 | 26,773 | |
| Dexcom G7 Continuous Glucose Monitoring System | 16,748 | |
| FreeStyle Libre 3 Plus | 13,218 | |
| t:slim X2 Insulin Pump with Control-IQ Technology | 10,423 | |
| DreamStation Auto CPAP | 8,072 | |
| CareLink SmartSync Common App iOS | 7,354 | |
| Inset Guard | 7,073 | |
| t:slim X2 Insulin Pump with Control-IQ+ Technology | 5,375 | |
| Quick Set | 4,518 | |
| MiniMed 780G US System BLE Connect 3.0 mg/dL | 4,366 |
Device Listings (GUDID)
27,811 device listings this week; the 10 below lead the list.
| Brand | Company | GMDN | Published |
|---|---|---|---|
| Melpex | Melpex Beauty Instruments | General-purpose surgical scissors, reusable | |
| Anyplus Peek Cage System | GS Medical Co., Ltd. | Polymeric spinal interbody fusion cage | |
| Wrap Around Quick Release | Shielding International Inc. | Radiation shielding apron | |
| Anyplus Peek Cage System | GS Medical Co., Ltd. | Polymeric spinal interbody fusion cage | |
| ProCure | Twin Med, LLC | Wound hydrogel dressing, non-antimicrobial | |
| TrellOss®-MCP | Nexxt Spine, LLC | General internal orthopaedic fixation system implantation kit | |
| Golden Isles Pedicle Screw System | Intelivation, LLC | Orthopaedic implantation sleeve, reusable | |
| TrellOss®-MCP | Nexxt Spine, LLC | Spinal fixation plate, non-bioabsorbable | |
| K2-HF SHOULDER, SH-6 T powder, 20g. | Yeti Dentalprodukte GmbH | Dental appliance fabrication material, ceramic | |
| Wrap Around Quick Release | Shielding International Inc. | Radiation shielding apron |
Australia (TGA ARTG)
5,186 ARTG device entries this week; the 10 below lead the list.
| Brand | Manufacturer | Sponsor | Class | Effective |
|---|---|---|---|---|
| Impress® | Merit Medical Systems Inc | Merit Medical Australia Pty Ltd | Class IIa | |
| ReSolve®, StayFIX® | Merit Medical Systems Inc | Merit Medical Australia Pty Ltd | Class IIb | |
| XiVE® | Dentsply Implants Manufacturing GmbH | Dentsply Sirona Pty Ltd | Class IIb | |
| Friadent® | Dentsply Implants Manufacturing GmbH | Dentsply Sirona Pty Ltd | Class IIb | |
| DS Implants™ | Dentsply Implants Manufacturing GmbH | Dentsply Sirona Pty Ltd | Class IIb | |
| Astra Tech Implant System® | Dentsply Implants Manufacturing GmbH | Dentsply Sirona Pty Ltd | Class IIb | |
| Friadent® | Dentsply Implants Manufacturing GmbH | Dentsply Sirona Pty Ltd | Class IIb | |
| DS OmniTaper™ | Dentsply Implants Manufacturing GmbH | Dentsply Sirona Pty Ltd | Class IIb | |
| PALACOS® fast R+G | Heraeus Medical GmbH | Heraeus Medical Australia Pty Ltd | Class III | |
| Ankylos® | Dentsply Implants Manufacturing GmbH | Dentsply Sirona Pty Ltd | Class IIb |
Canada (Health Canada MDALL)
164 new device licences this week; the 10 below lead the list.
| Device | Company | Class | Licensed |
|---|---|---|---|
| Firstfit Surgical Kit with Voice Prosthesis Ready for Insertion Contains Classic Indwelling Voice Prosthesis | Freudenberg Medical, LLC | 3 | |
| National Opthalmic Pack A | Medline Industries, LP | 2 | |
| Zolid Lunaris | Amann Girrbach AG | 3 | |
| Transpac IV Monitoring Kit W/Safeset Reservoir and Blood Sampling Port | ICU Medical Inc. | 2 | |
| Transpac IV Monitoring Kit W/ Safeset Reservoir, Needleless Valve | ICU Medical Inc. | 2 | |
| Bm Contour Pro L | Siemens Healthcare GmbH | 2 | |
| Bm Contour Pro L Set | Siemens Healthcare GmbH | 2 | |
| Bm Contour Pro M | Siemens Healthcare GmbH | 2 | |
| Bm Contour Pro M Set | Siemens Healthcare GmbH | 2 | |
| Bm Contour Pro S | Siemens Healthcare GmbH | 2 |
Drug Labels
925 label effective dates this week; the 10 below lead the list.
| Brand | Generic | Manufacturer | Effective |
|---|---|---|---|
| Orraya WART REMOVER Patches | Salicylic Acid 40% Wart Remover Patches | Wenzhou Yuyuan Pharmaceutical Co., Ltd. | |
| Cold Sore Fever Blister Treatment | Docosanol | Sportpharm LLC | |
| ciprofloxacin | Ciprofloxacin | Hawaii Repack, Inc. | |
| Xeljanz Xr Xeljanz | Tofacitinib | Pfizer Laboratories Div Pfizer Inc | |
| Diclofenac Sodium | Diclofenac Sodium | Hawaii Repack, Inc. | |
| Dove | Cinnamon Pumpkin Antiperspirant Deodorant | Conopco d/b/a Unilever | |
| Dove | Sugar Cookie Antiperspirant Deodorant | Conopco d/b/a Unilever | |
| ENOKON PAIN RELIEF Spray. | Pain Relief Spray. | Henan Enokon Medical Instrument Co., Ltd. | |
| 7 Day Spot and Tag Remover Pen | Salicylic Acid | Guangxi Keyun E-commerce Co., Ltd. | |
| ENOKON PAIN RELIEF Cream | Pain Relief Cream | Henan Enokon Medical Instrument Co., Ltd. |
Workforce (NPPES)
13,639 new provider enumerations this week; the 10 below lead the list.
| State | New providers | Organizations |
|---|---|---|
| CA | 1,984 | 290 |
| TX | 964 | 322 |
| FL | 863 | 240 |
| NY | 733 | 115 |
| MI | 584 | 95 |
| OH | 561 | 77 |
| PA | 443 | 77 |
| MA | 432 | 41 |
| IL | 404 | 96 |
| NC | 404 | 104 |
Industry Payments (Open Payments)
15,384,974 industry payments this week; the 10 below lead the list.
| Payer | Total (USD) | Payments |
|---|---|---|
| BioNTech SE | 180,558,679 | 164 |
| AbbVie Inc. | 156,382,683 | 1,720,745 |
| Stryker Corporation | 132,155,940 | 162,439 |
| Medtronic, Inc. | 117,649,217 | 342,148 |
| Arthrex, Inc. | 104,199,464 | 49,443 |
| Edge Endo LLC | 91,139,127 | 11 |
| Zimmer Biomet Holdings, Inc. | 83,904,351 | 32,760 |
| Intuitive Surgical, Inc. | 72,225,869 | 116,855 |
| Takeda Pharmaceuticals U.S.A., Inc. | 71,616,187 | 171,595 |
| Advanced Accelerator Applications | 63,931,988 | 167 |
Patents (USPTO, A61)
95 medtech patent grants this week; the 10 below lead the list.
| Assignee | Grants |
|---|---|
| Globus Medical, Inc. | 8 |
| Hytto Pte. Ltd. | 2 |
| Medicrea International | 2 |
| Koninklijke Philips N.V. | 2 |
| Warsaw Orthopedic, Inc. | 2 |
| Neodyne Biosciences, Inc. | 1 |
| GlaxoSmithKline Intellectual Property Development Limited | 1 |
| University of Florida Research Foundation, Incorporated | 1 |
| Intuitive Surgical Operations, Inc. | 1 |
| Universitätsspital Basel | 1 |
Literature (PubMed)
159,428 literature records this week; the 10 below lead the list.
| PMID | Title | Journal | Revised |
|---|---|---|---|
| Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression. | Clinical science (London, England : 1979) | ||
| A New Lysosome-Targetable Turn-On Fluorogenic Probe for Carbon Monoxide Imaging in Living Cells. | Analytical chemistry | ||
| From fragments to drugs: How AI and in silico methods accelerate fragment-to-lead optimization. | European journal of medicinal chemistry | ||
| Discovery of a potent and selective small-molecule inhibitor of ubiquitin-specific peptidase 15 (USP15) for the treatment of breast cancer. | European journal of medicinal chemistry | ||
| Development of highly selective, low-toxicity and orally available Mcl-1 inhibitors based on 3,5-dimethyl-4-sulfonimide-1H-pyrrole scaffold via P2/P3 dual pocket binding optimization. | European journal of medicinal chemistry | ||
| Dengue virus nonstructural proteins as small-molecule targets: Advances, challenges, and future directions. | European journal of medicinal chemistry | ||
| Discovery of pyrazole-based selective covalent ITK inhibitors with In vivo activity. | European journal of medicinal chemistry | ||
| Structure based identification of novel 4,5,6,7-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one derivatives as nonacidic ATX inhibitors with promising antifibrotic effects. | European journal of medicinal chemistry | ||
| Developing a chronic test for field-collected mayflies: The influence of laboratory conditions on development and survival of Cloeon dipterum. | Environmental toxicology and chemistry | ||
| Detection of hard electrophilic reactive metabolites formed from alicyclic amines using glutathione trapping. | Xenobiotica; the fate of foreign compounds in biological systems |
Literature by Subject (MeSH)
225,152 annotated literature records this week; the 10 below lead the list.
| MeSH heading | Articles |
|---|---|
| Humans | 144,466 |
| Female | 81,693 |
| Male | 77,975 |
| Animals | 53,268 |
| Middle Aged | 41,549 |
| Adult | 41,247 |
| Aged | 30,754 |
| Mice | 17,640 |
| Retrospective Studies | 17,442 |
| Young Adult | 15,129 |
Insider Buying (Form 4)
872 open-market insider purchases this week; the 10 below lead the list.
| Ticker | Owner | Traded | Shares | Value (USD) |
|---|---|---|---|---|
| MetLife Investment Management, LLC | 120,000,000 | 4,800,000,000,000,000 | ||
| VisionWave Holdings, Inc. | 979,257,600 | 3,407,816,448 | ||
| ICONIQ Strategic Partners VIII Holdings, L.P. | 3,661,746 | 43,296,294 | ||
| Thrivent Financial for Lutherans | 1,350,000 | 31,563,000 | ||
| Huang Jack Jiajia | 1,668,060 | 27,990,047 | ||
| Globalharvest Holdings Venture Ltd | 2,061,666 | 27,667,558 | ||
| Globalharvest Holdings Venture Ltd | 1,951,245 | 24,839,349 | ||
| Globalharvest Holdings Venture Ltd | 1,778,871 | 23,623,407 | ||
| Griffith William J.G. | 1,830,873 | 21,648,242 | ||
| Globalharvest Holdings Venture Ltd | 1,475,595 | 19,772,973 |
Academica Weekly is assembled and published automatically each week. This issue covers 6 July 2026 to 12 July 2026 and was built on 3 August 2026.